Tissue Remodeling

Learning Objectives

  • At the end of the session, students should be able to explain the difference between regeneration and fibrosis.
  • At the end of the session, students should be able to define factors involved in determining the outcome of tissue injury including role of different types of tissue (labile, stable, permanent), status of local tissue stem cells, role of angiogenesis, architectural framework destruction and insights from experimental approaches in determining the outcome of tissue injury.
  • At the end of the session, students should be able to describe major growth factors involved in regeneration and fibrosis and their biologic activity including major signaling pathways.
  • At the end of the session, students should be able to describe the major histologic pathways of regeneration and fibrosis.
  • At the end of the session, students should be able to explain the role of inflammation as both a cause and a result of chronic injury and its relationship to fibrosis.
  • At the end of the session, students should be able to describe components and function of normal extracellular matrix and the changes that occur in fibrosis.
  • At the end of the session, students should be able to describe the significance of fibrosis in tissue function.

Before the Session

Read the background material

OR

Watch the videos

In-class Session

Readiness Assessment Quiz

Team-Based Questions